Fruit compounds could help treat obesity, type 2 diabetes, and CVD

In the journal Diabetes, researchers reveal that the two fruit compounds work together to reduce blood glucose levels, improve insulinactivity, and boost the health of arteries.

Obesity affects more than a third of adults in the United States, raising their risk of heart diseasetype 2 diabetesstroke, and some forms of cancer.

At the same time, cardiovascular disease (CVD) - a term used to describe diseases of the heart and blood vessels - is responsible for around 1 in 3 deaths in the U.S., whilediabetes affects around 9.3 percent of Americans.

Such statistics highlight the need for more effective treatment strategies for these conditions.

Now, study leader Paul Thornalley, professor in systems biology at Warwick, and colleagues suggest red grapes and oranges may pave the way for such treatments.

Fruit compound combo increases Glo1 expression

For their study, the team investigated the effects of a compound called trans-resveratrol (tRES), found in red grapes, and a compound found in oranges called hesperetin (HESP).

On testing a combination of the compounds in cell culture, the researchers found that it increased expression of glyoxalase 1 (Glo1) - an enzyme that neutralizes a compound called methylglyoxal (MG).

The team explains that MG is a key driver of sugar's harmful effects on the body; a combination of high MG levels and a high-calorie diet is a cause of insulin resistance, which can lead to type 2 diabetes. It also damages blood vessels and can drive high cholesterol levels - a risk factor for CVD.

As such, the team hypothesizes that blocking MG by increasing Glo1 expression could reverse these effects. 


Autor / Fonte:MedicalNewsToday