Mountain Cycling Ultramarathon Impacts in Inflammatory and Hemoglobin Responses.

Purpose: To analyze the cumulative physiological burden of repetitive, strenuous exercise held during mountain cycling ultramarathon on regulatory mechanisms of hemoglobin degradation.

Methods: Fifty-five non-professional athletes (mean age 44.8+/-7.1 years old) participating in a 9-consecutive-day mountain cycling ultramarathon (TransPortugal), underwent anthropometric, hematological and biochemical assessments before and immediately after the race. Participants were further stratified as completers (9 courses) or non-completers, and divided according to the time they took to complete the race. The heme oxygenase-1 (HMOX1) functional genetic polymorphism and Haptoglobin (HP) phenotypic variants were also analyzed.

Results: Total leucocytes, neutrophil and monocyte counts increased, whereas decreases in erythrocyte counts and hemoglobin were found between pre and post-ultramarathon. Circulating haptoglobin (Hp) was increased while its soluble receptor (sCD163) decreased. Athletes who completed all 9 courses presented with increased leucocyte, neutrophil, and erythrocyte counts, as well as hemoglobin, RDW, total bilirubin and total cholesterol levels. High sensitivity-C reactive protein (hs-CRP) and Hp decreased in comparison with non-completers. HMOX1 and HP genetic polymorphisms were associated with biochemical profile, notably with Hp levels. Analysis of covariance showed a significant effect of HP phenotype in Hp circulating levels at the end of race and on the magnitude of variation from pre- to post-race.

Conclusion: Present findings support a co-modulatory influence of genetic- and exercise-associated factors on resulting inflammatory and hemoglobin catabolic marker Hp after highly demanding endurance exercise.

(C) 2017 American College of Sports Medicine


Autor / Fonte:Isanete Alonso, Andreia Matos, Ricardo Ribeiro, Ângela Gil, Carlos Cardoso, Luís B Sardinha, Manuel Bicho Medicine and Science in Sports and Exercise 2017 October 3