Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene
The frequency of HFE mutations in elite athletes is twice as high as in controls.
In the international podium group, 80% of athletes have mutations in the HFE gene.
The HFE mutations are favourable to high level performance in athletes.
Heterozygous HFE mutations could be associated with a favourable phenotype.
The HFE gene encodes a protein involved in iron homeostasis; individuals with mutations in both alleles develop hemochromatosis. 27% of the French population is heterozygous for mutations in this gene. We found that 80% of the French athletes who won international competitions in rowing, Nordic skiing and judo display mutations in one allele of HFE, thus demonstrating the existence of a favourable phenotype linked to this heterozygosity.
- HFE mutation frequency;
- HFE, High Fe, or high iron concentration;
- RBC, red blood cell;
- MVC, mean corpuscular volume;
- EPO, erythropoietin;
- sTFR, soluble transferrin receptor;
- IPG, international podium group;
- NPG, no international podium group;
- OR, odds ratio
Copyright © 2015 Published by Elsevier Masson SAS
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Autor / Fonte:Olivier Hermine, Gérard Dine, Vincent Genty, more. Biochimie 2015 September 25