Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters.



We assessed the impact of completing the Hotter´n Hell Hundred (HHH), an annual 164 km road cycling event performed in a hot environment, on hemostatic balance in men.


Sixteen men who completed the ride in <6 h were included in this study. Plasma samples were collected on that morning of the ride (PRE) and immediately on the completion of the ride (IP). Primary hemostasis was assessed by platelet count and von Willebrand factor antigen (vWF:Ag). Coagulation was assessed by measuring prothrombin fragment 1 + 2 (PTF 1 + 2) and thrombin-antithrombin complex (TAT), whereas fibrinolysis was assessed by plasminogen activator inhibitor antigen (PAI-1 Ag), tissue plasminogen activator (tPA Ag), and D-Dimer analyses.


Compared to PRE, increases (p < 0.001) were observed at IP for platelets (39 %), vWF:Ag (65 %), PTF 1 + 2 (47 %), TAT (81 %), tPA Ag (231 %), PAI-1 Ag (148 %), and D-Dimer (54 %). PRE PAI-1 Ag concentrations were directly related to BMI and waist circumference (p < 0.05). D-Dimer concentrations at IP correlated positively with age (p < 0.05).


Completing the HHH activated the coagulation and fibrinolytic systems in balance. Age was positively correlated with IP D-Dimer concentrations. Additionally, participants displaying a larger BMI and waist circumference exhibited a positive correlation with PRE PAI-1 Ag concentrations.

[PubMed - indexed for MEDLINE] 

Autor / Fonte:Kupchak BR, McKenzie AL, Luk HY, Saenz C, Kunces LJ, Ellis LA, Vingren JL, Lee EC, Ballard KD, Johnson EC, Kavouras SA, Ganio MS, Wingo JE, Williamson KH, Armstrong LE. Eur J Appl Physiol. 2015 Jun;115(6):1295-303. doi: 10.1007/s00421-015-3107-y.
Link: http://www.ncbi.nlm.nih.gov/pubmed/25603777