BASAL METABOLIC UP-REGULATION THROUGH REPETITIVE SHORT HIGH IMPACT EXERCISE TRAINING (THE BURST STUDY)

Background

Lifestyle interventions are recommended as first line therapy in newly diagnosed type 2 diabetics. Current guidelines recommend sustained exercise of low to moderate intensity for 30-45 minutes three-five days per week. Recent studies in healthy volunteers, however, have demonstrated potential cardio-metabolic benefits of high impact exercise in multiple short bursts. The impact of this exercise regimen in diabetics has yet to be adequately assessed.

Methods

This three month study randomized newly diagnosed subjects with type 2 diabetes, to a regimen of high impact, burst exercise (ten minutes at 85% of peak heart rate three times per day) vs sustained exercise (30 minutes at 60% of peak heart rate once a day). Primary outcomes were aerobic fitness and Hemoglobin A1C (HbA1C). BMI, exercise adherence, and lipid profiles were also assessed.

Results

Forty patients within 3 months of their diagnosis of type 2 diabetes were recruited: mean age: 67; 70% male. Patients prescribed burst exercise were found to be 16% more adherent to their exercise regimen at 3 months compared to the sustained exercise group (362 vs 460 minutes per month, p<0.01). These patients also showed a 2.3 fold greater improvement in HbA1C (-0.82 vs −0.25%, p<0.01), and a 5.3 fold greater improvement in aerobic fitness (p<0.01). There was a 2.3 fold greater improvement in LDL (-0.37 vs −0.16 mmol/mol, p<0.01), a 6.7 fold greater improvement in HDL (0.14 vs 0.021 mmol/mol, p<0.01), and a 5.1 fold greater improvement in triglycerides (-0.86, −0.17 mmol/mol, p<0.01) with burst exercise. Linear regression analysis revealed a greater relative improvement in HbA1C per minute of exercise with burst exercise.

Conclusions

Burst high intensity exercise for diabetes rehabilitation appeared to have significantly greater cardio-metabolic benefits compared to the current standard of sustained low-moderate intensity exercise. Further research is required to validate this regimen in larger and more diverse patient populations over longer follow-up. 

 


Autor / Fonte:Avinash Pandey; Paul Poirier; Neville Suskin J Am Coll Cardiol. 2016;67(13_S):1870-1870. doi:10.1016/S0735-1097(16)31871-X.
Link: http://content.onlinejacc.org/data/Journals/JAC/935148/1871X.pdf